HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → N-Formylindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Indoline | HCID 10328 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-Formylindoline | HCID 576501 | 89.1% |
Reaction Steps
A solution of indoline (5.0 g) and 98% formic acid (3.0 g) in toluene (17 mL) was heated at reflux for 6 hours with a Dean-Stark trap, cooled, washed with water and concentrated. The resulting dark brown solid was dissolved in methanol, concentrated to a fraction of its original volume, treated with 1:1 diethyl ether/hexane, and concentrated dryness to provide 5.5 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06924304B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-a1a3367a5e784c47971c1e3cf1910163 |
| Source note | uspto-grants-2005_08 |