Hydrochloric Acid → HCID 15500349, compound

Participants

Reaction Steps

Dimethyl 3-heptadecyl-3-nitropentane-1,5-dicarboxylate (7a) (138 mg, 0.29 mmol) was dissolved in DME (2 mL) and sat. aq LiOH solution (2 mL) was added. The mixture was let stand for 22 h, then it was acidified with dilute HCl (10%, 10 mL) and extracted with EtOAc (2×10 mL). The extracts were concentrated under a stream of dry N2 and the residue was subjected to flash column chromatography on silica (EtOAc/petroleum spirit, 15/85) to afford 3-heptadecyl-3-nitropentane-1,5-dicarboxylic acid (8a) (93 mg, 90%) as a white solid; mp 102° C.

Provenance & Evidence