HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → cis-4-(4-Chloro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene | HCID 67959 | — |
| Reactant | (2R,6S)-2,6-Dimethyl-1-propylpiperazine | HCID 28363798 | — |
| Product | cis-4-(4-Chloro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine | HCID 68443155 | — |
Reaction Steps
Beginning with 5-bromo-2-chlorobenzotrifluoride and cis-2,6-dimethyl-1-propyl-piperazine, the title compound was recovered by the procedure described in Preparation 9: m.p. 256° C. (HCl), MS m/z (rel. intensity, 70 eV)) 335 (M+, 5), 305 (55), 112 (bp), 70 (67), 56 (82).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06924374B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-f7c3e7476ee44cde8da15c899200e694 |
| Source note | uspto-grants-2005_08 |