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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 584084Generated: October 30, 2026

Piperazine → 1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine

https://huagongshe.com/reaction/584084

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperazineHCID 4837—
Reactant4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotolueneHCID 67959—
Product1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazineHCID 277813778.2%

Reaction Steps

Beginning with 5-bromo-2-chlorobenzotrifluoride (602 mg) and piperazine (1 g), 480 mg of the title compound was recovered by the procedure described in Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06924374B2
Source datasetuspto-grants-2005_08
ORD IDord-aaf69014045a4df48cfb5c6eab8843aa
Source noteuspto-grants-2005_08