Succinic anhydride → 3-[3-(3-Tert-butyloxycarbonylaminophenyl)-1,2,4-oxadiazol-5-yl]propionic acid

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Reaction Conditions

Reaction Steps

Succinic anhydride (14 mg, 0.14 mmol) and [3-(N-hydroxycarbamimidoyl)-phenyl]-carbamic acid tert-butyl ester (35 mg, 0.14 mmol) were dissolved in 0.25 mL DMF and heated at 120° C. for 2 h. The cooled solution was evaporated and dried to yield 3-[3-(3-tert-butoxycarbonylamino-phenyl)-[1,2,4]oxadiazol-5-yl]-propionic acid which was used without further purification.

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