HCID 178477634, compound → HCID 178500579, compound

HRID 584136Notes

Reaction equation

HRID 584136 reaction equation
C(CCC(ONC([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:14]1)=N)=O)(OC)=O.[C:26]([CH2:30][CH2:31][C:32]([O:34][NH:35][C:36](C1CCCN1C(OC(C)(C)C)=O)=[NH:37])=[O:33])([O:28][CH3:29])=[O:27].C(CCC(ONC(C1C=C(NC(=O)OC(C)(C)C)SC=1)=N)=O)(OC)=O.C(CCC(ONC(C1SC(NC(=O)OC(C)(C)C)=CC=1)=N)=O)(OC)=O.C(CCC(ONC(C1C=NN(C)C=1NC(=O)OC(C)(C)C)=N)=O)(OC)=O.C(CCC(ONC(C1NC=CC=1)=N)=O)(OC)=O.C(CCC(ONC(C1N(C)C=CC=1)=N)=O)(OC)=O.C(CCC(ONC(=N)C1C=CC=C(CO[Si](C(C)C)(C(C)C)C(C)C)C=1)=O)(OC)=O.C(CCC(ONC(=N)C1C=CC(CO[Si](C(C)C)(C(C)C)C(C)C)=CC=1)=O)(OC)=O.C(CCC(ONC(C1C=C(NC(=O)NCC(C)C)SC=1)=N)=O)(OC)=O.C(S(C1SC(N)=C(C(NOC(=O)CCC(OC)=O)=N)C=1)(=O)=O)C.ClCC(NOC(=O)CCC(OC)=O)=N.C(CCC(ONC(C1C(C)=NOC=1NC(=O)OC(C)(C)C)=N)=O)(OC)=O>>[C:26]([CH2:30][CH2:31][C:32]([O:34][NH:35][C:36]([CH:18]1[CH2:13][CH2:14][N:15]([C:19]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:20])[CH2:16][CH2:17]1)=[NH:37])=[O:33])([O:28][CH3:29])=[O:27]

Participants

14

Reactant 13

HCID 178477634HCID 178477634, compoundHCID 178500571HCID 178500571, compoundHCID 178500573HCID 178500573, compoundHCID 178500574HCID 178500574, compoundHCID 178500575HCID 178500575, compoundHCID 178500576HCID 178500576, compoundHCID 178500577HCID 178500577, compound2×HCID 178500578HCID 178500578, compoundHCID 178500580HCID 178500580, compoundHCID 178500581HCID 178500581, compoundHCID 178500582HCID 178500582, compoundHCID 178500583HCID 178500583, compoundHCID 178500584HCID 178500584, compound

Product 1

HCID 178500579HCID 178500579, compound

Procedure

tert-Butyl 3-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]-piperidine-1-carboxylate; tert-Butyl 2-[N-(3-Carbomethoxypropionyloxy)carbamamidoyl]piperidine-1-carboxylate; tert-Butyl 2-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]pyrrolidine-1-carboxylate; tert-Butyl 4-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]thiophen-2-ylcarbamate; tert-Butyl 5-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]thiophen-2-ylcarbamate; tert-Butyl 5-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]thiophen-2-ylcarbamate; tert-Butyl 4-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]-2-methyl-2H-pyrazol-3-ylcarbamate; tert-Butyl 5-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]-1-(2-trimethylsilyl)ethoxymethyl-1H-imidazol-4-ylcarbamate; tert-Butyl 4-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]-1-(2-trimethylsilyl)-ethoxymethyl-1H-imidazol-5-ylcarbamate; N-(3-Carbomethoxypropionyloxy)-1H-pyrrole-2-carboxamidine; N-(3-Carbomethoxypropionyloxy)-1-methyl-1H-pyrrole-2-carboxamidine; tert-Butyl 4-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]-1-(2-trimethylsilyl)ethoxymethyl-1H-pyrazol-3-ylcarbamate; N-(3-Carbomethoxypropionyloxy)-3-triisopropylsilyloxymethylbenzamidine; N-(3-Carbomethoxypropionyloxy)-4-triisopropylsilyloxymethylbenzamidine; 3-{4-[N-(3-Carbomethoxypropionyloxy)carbamimidoyl]thiophen-2-yl}-1-isobutylurea.; 5-Ethanesulfonyl-amino-N-(3-carbomethoxypropionyloxy)thiophene-3-carboxamidine; 2-Chloro-N-(3-carbomethoxypropionyloxy)acetamidine; and tert-Butyl [4-(N-(3-Carbomethoxypropionyloxy)carbamimidoyl)-3-methylisoxazol-5-yl]carbamate.

Sources & evidence

ORD record
ord-af39390620f241fdb5f1621d7122a181
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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