HCID 22343018, compound → HCID 22343219, compound

HRID 584138Notes

Reaction equation

C(OC(N1C[CH2:12][CH2:11][CH:10]([C:14]2[N:18]=[C:17]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])[O:16][N:15]=2)[CH2:9]1)=O)(C)(C)C.[C:25]([O:29][C:30]([N:32]1CCCC[CH:33]1C1N=C(CCC(OC)=O)ON=1)=[O:31])([CH3:28])([CH3:27])[CH3:26].C(OC(N1CCCC1C1N=C(CCC(OC)=O)ON=1)=O)(C)(C)C.C(OC(NC1SC=C(C2N=C(CCC(OC)=O)ON=2)C=1)=O)(C)(C)C.C(OC(NC1SC(C2N=C(CCC(OC)=O)ON=2)=CC=1)=O)(C)(C)C.C(OC(NC1N(C)N=CC=1C1N=C(CCC(OC)=O)ON=1)=O)(C)(C)C.N1C=CC=C1C1N=C(CCC(OC)=O)ON=1.CN1C=CC=C1C1N=C(CCC(OC)=O)ON=1.C([Si](C(C)C)(C(C)C)OCC1C=C(C2N=C(CCC(OC)=O)ON=2)C=CC=1)(C)C.C([Si](C(C)C)(C(C)C)OCC1C=CC(C2N=C(CCC(OC)=O)ON=2)=CC=1)(C)C.COC(=O)CCC1ON=C(C2C=C(NS(CC)(=O)=O)SC=2)N=1.COC(=O)CCC1ON=C(CCl)N=1>>[C:25]([O:29][C:30]([N:32]1[CH2:33][CH2:9][CH:10]([C:14]2[N:18]=[C:17]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])[O:16][N:15]=2)[CH2:11][CH2:12]1)=[O:31])([CH3:28])([CH3:27])[CH3:26]

Participants

Reactant 12

HCID 22343018HCID 22343018, compound

HCID 22343036HCID 22343036, compound

HCID 22343065HCID 22343065, compound

HCID 22343113HCID 22343113, compound

HCID 22343128HCID 22343128, compound

HCID 22343165HCID 22343165, compound

HCID 22343217HCID 22343217, compound

HCID 22343252HCID 22343252, compound

HCID 22343272HCID 22343272, compound

HCID 22343324HCID 22343324, compound

HCID 22343385HCID 22343385, compound

HCID 135841397HCID 135841397, compound

Product 1

HCID 22343219HCID 22343219, compound

Procedure

Methyl 3-[3-(1-tert-Butyloxycarbonylpiperidin-3-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(1-tert-Butyloxycarbonylpiperidin-2-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(1-tert-Butyloxycarbonylpyrrolidin-2-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(2-tert-Butyloxycarbonylaminothiophen-4-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(2-tert-Butyloxycarbonylaminothiophen-5-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(3-tert-Butyloxycarbonylamino-2-methyl-2H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(3-tert-Butyloxycarbonylamino-1-(2-trimethylsilyl)ethoxymethyl-1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(4-tert-Butyloxycarbonylamino-1-(2-trimethylsilyl)ethoxymethyl-1H-imidazol-5-yl)-1,2,4-oxadizaol-5-yl]propionate; Methyl 3-[3-(5-tert-Butyloxycarbonylamino-1-(2-trimethylsilyl)ethoxymethyl-1H-imidazol-4-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(1H-Pyrrol-2-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(1-Methyl-1H-pyrrol-2-yl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(3-Triisopropylsilyloxymethylphenyl)-1,2,4-oxadiazol-5-yl]propionate; Methyl 3-[3-(4-Triisopropylsilyloxymethylphenyl)-1,2,4-oxadiazol-5-yl]propionate; 3-{4-[(5-(2-Carbomethyoxy)ethyl)-1,2,4-oxadiazol-3-yl]thiophen-2-yl}-1-isobutylurea; Methyl-3-(2-Ethanesulfonylaminothiophene-4-yl-1,2,4-oxadiazol-5-yl)propionate; Methyl-3-(3-Chloromethyl-1,2,4-oxadiazol-5-yl)propionate; and Methyl-3-[3-(5-tert-Butyloxycarbonylamino-3-methylisoxazol-4-yl)-1,2,4-oxadizol-5-yl]propionate.

Sources & evidence

ORD record: ord-c264e3b5c7d94a689fe31ae05ececbeb
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06924284B2

Reaction notes

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