Aluminium lithium hydride → HCID 22345511, compound

Participants

Reaction Steps

A solution of methyl 2-[4-[3-(tert-butyldiphenylsilyloxy)propyl]phenoxy]-2-methylpropionate (5.88 g, 11.98 mmol) in diethyl ether (100 ml) was treated at 22° C. with 23 ml (23 mmol) of a 1M solution of lithium aluminum hydride in ether. The resulting mixture was then heated under reflux for 1 hour. The cooled mixture was quenched by addition of ethyl acetate, water (5 ml) and 1N sodium hydroxide (5 ml). The solid formed was filtered and the filtrate was evaporated and purified on silica gel. Elution with a mixture of toluene and ethyl acetate (9:1) gave 5.14 g (93%) of the title material as an oil.

Provenance & Evidence