HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[3,5-Bis(trifluoromethyl)benzoyl]-4-(benzyloxycarbonyl)-2-(2,3-dimethoxybenzyl)piperazine → 1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(2,3-dimethoxybenzyl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[3,5-Bis(trifluoromethyl)benzoyl]-4-(benzyloxycarbonyl)-2-(2,3-dimethoxybenzyl)piperazine | HCID 22342876 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(2,3-dimethoxybenzyl)-piperazine | HCID 22342580 | 101.3% |
Reaction Steps
A solution of 1-[3,5-bis(trifluoromethyl)benzoyl]-4-(benzyloxycarbonyl)-2-(2,3-dimethoxybenzyl)piperazine (0.81 g) in methanol (20 ml) was hydrogenated over 10% palladium-carbon (50% wet, 0.30 g) at room temperature under atmospheric pressure for 90 minutes. After removal of the catalyst by filtration, the filtrate was evaporated under reduced pressure to give colorless oil of 1-[3,5-bis (trifluoromethyl)benzoyl]-2-(2,3-dimethoxybenzyl)piperazine (0.64 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06924278B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-1d3e73972346452ea4aa1a76bf6ca205 |
| Source note | uspto-grants-2005_08 |