Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetamidomalonic acid diethyl ester → Diethyl 2-acetylamino-2-(3,4-dimethylbenzyl)malonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| 반응물 | 3,4-Dimethylbenzyl chloride | HCID 66018 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diethyl 2-acetylamino-2-(3,4-dimethylbenzyl)malonate | HCID 13406779 | 53.4% |
반응 단계
3,4-Dimethylbenzyl chloride (10.2 g) and diethyl acetamidomalonate (14.3 g) were added successively into a solution of sodium ethoxide (4.94 g) in ethanol. The mixture was stirred under reflux for 2 hours and filtered through Celite®. The filtrate was concentrated under reduced pressure to give crystals which were collected by filtration and washed with isopropyl ether to give colorless crystals of diethyl 2-acetylamino-2-(3,4-dimethylbenzyl)malonate (11.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06924278B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-3c805eeadff34d75a8c4d32cef27e858 |
| 출처 메모 | uspto-grants-2005_08 |