2-Chloroethyl methyl ether → 1-Bromo-2-ethyl-5-ethoxymethoxybenzene

Participants

Reaction Steps

In a manner similar to that of Example 1(e), by reacting 13 g (65 mmol) of 3-bromo-4-ethylphenol with 6.7 ml (72 mmol) of methoxyethyl chloride, and after purification by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (90/10), 12 g (76%) of the expected product are obtained in the form of a yellow oil.

Provenance & Evidence