(5-(Ethoxymethoxy)-2-ethylphenyl)boronic acid → 1-(5'-Ethoxymethoxy-2,2'-diethylbiphenyl-4-yl)propan-1-one

HRID 584303Notes

Reaction equation

HRID 584303 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:5][C:4]=1B(O)O)[CH3:2].FC(F)(F)S(O[C:23]1[CH:28]=[CH:27][C:26]([C:29](=[O:32])[CH2:30][CH3:31])=[CH:25][C:24]=1[CH2:33][CH3:34])(=O)=O>>[CH2:12]([O:11][CH2:10][O:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[C:4]([C:23]2[CH:28]=[CH:27][C:26]([C:29](=[O:32])[CH2:30][CH3:31])=[CH:25][C:24]=2[CH2:33][CH3:34])[CH:5]=1)[CH3:13]

Participants

3

Reactant 2

HCID 22345587(5-(Ethoxymethoxy)-2-ethylphenyl)boronic acidHCID 223455992-Ethyl-4-propionylphenyl 1,1,1-trifluoromethanesulfonate

Product 1

HCID 223456451-(5'-Ethoxymethoxy-2,2'-diethylbiphenyl-4-yl)propan-1-one

Procedure

In a manner similar to that of Example 1(g), by reacting 2 g (8.9 mmol) of 2-ethyl-5-ethoxymethoxyphenylboronic acid with 2.1 g (6.9 mmol) of 2-ethyl-4-propionylphenyl 1,1,1-trifluoromethanesulfonate, a black oil is obtained, which is used without further purification for the rest of the synthesis.

Workup

  1. customa black oil is obtained
  2. customwhich is used without further purification for the rest of the synthesis

Sources & evidence

ORD record
ord-82be0b637fb547dea68f9819d5af576b
Source dataset
uspto-grants-2005_08
Patent number
US06924400B2

Reaction notes

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