HCID 22345611, compound → HCID 10195345, compound

Participants

Reaction Steps

In a manner similar to that of Example 1(q), by reacting 840 mg (1.9 mmol) of 1-{5′-[3,4-bis(hydroxymethyl)benzyloxy]-2,2′-diethylbiphenyl-4-yl}-1-propanone with 5.2 ml (16 mmol) of ethylmagnesium bromide (3M/ether), and after purification by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (40/60), 254 mg (29%) of {5-[6,2′-diethyl-4′-(1-ethyl-1-hydroxypropyl)biphenyl-3-yloxymethyl]-2-hydroxymethylphenyl}methanol are obtained in the form of white crystals with a melting point of 93° C.

Provenance & Evidence