HCID 22345643, compound → HCID 10174128, compound

Participants

Reaction Steps

In a manner similar to that of Example 1(q), by reacting 830 mg (1.9 mmol) of 1-{5′-[3,4-bis(hydroxymethyl)benzyloxy]-2′-ethyl-2-propylbiphenyl-4-yl}-1-propanone with 5.1 ml (15.2 mmol) of ethylmagnesium bromide (3M/ether), and after purification by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (40/60), 700 mg (77%) of {4-[6-ethyl-4′-(1-ethyl-1-hydroxypropyl)-2′-propylbiphenyl-3-yloxymethyl]-2-hydroxymethylphenyl}methanol are obtained in the form of white crystals with a melting point of 101° C.

Provenance & Evidence