HCID 22345631, compound → HCID 15948786, compound

Participants

Reaction Steps

In a manner similar to that of Example 1(q), by reacting 810 mg (1.8 mmol) of 1-{5′-[3,4-bis(hydroxymethyl)benzyloxy]-2′-ethyl-2-isopropylbiphenyl-4-yl}-1-propanone with 4.8 ml (15 mmol) of ethylmagnesium bromide (3M/ether), and after purification by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (35/65), 600 mg (70%) of {4-[6-Ethyl-4′-(1-ethyl-1-hydroxypropyl)-2′-isopropylbiphenyl-3-yloxymethyl]-2-hydroxymethylphenyl}methanol are obtained in the form of white crystals with a melting point of 109° C.

Provenance & Evidence