反应详情

温度

120 °C

A mixture of 2-chloropyrimidine (20.8 g) and 2-(methylamino)ethanol (180 ml) was heated at 120° C. for 15 hours and concentrated. The residue was dissolved in ethyl acetate, washed with an aqueous saturated solution of sodium chloride, dried (MgSO4) and concentrated. The residue was distilled under reduced pressure to obtain 2-(methyl-2-pyrimidylamino)ethanol (24.6 g, yield 88%) as a colorless oil. b.p. 130-132° C./1-1.5 mmHg

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with an aqueous saturated solution of sodium chloride
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. distillationThe residue was distilled under reduced pressure