HRID584494

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C(\CCC(=O)O)c2ccccc2)cc1$

HCID9890879

Imiglitazar

C28H26N2O5

HCID10942334

Methanol, sodium salt

CH3NaO

PRODUCTS

生成物

$结构：Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C(\CCC(=O)[O-])c2ccccc2)cc1.[Na+]$

HCID23671703

未命名化合物

收率 46.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Sodium methoxide (108 mg) was added to a solution of E-4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyric acid (941 mg) in methanol (5 ml), which was stirred at room temperature for 1 hour and concentrated. The remaining crystals were recrystallized from methanol-diethyl ether to obtain sodium E-4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyrate (456 mg, yield 46%) as colorless crystals. m.p. 64-70° C.

WORKUP

后处理

concentrationconcentrated
customThe remaining crystals were recrystallized from methanol-diethyl ether