反应详情

2,3-Dihydro-1-methyl-3-(phenylmethyl)-2-thioxo-6-(trifluoromethyl)-4(1H)-pyrimidinone (1.0 g) was dissolved in m-xylene (15 ml) and anhydrous aluminum chloride (0.58 g) was added. The solution was refluxed for 4 hr and poured onto ice water. Extraction with ethyl acetate and evaporation of the solvent in vacuo afforded a residue which was triturated with diethyl ether to afford the title compound (0.34 g). 1H NMR, CDCl3, 3.86 (3H, m), 6.49 (1H, s), 10.62 (1H, br s).

1. temperatureThe solution was refluxed for 4 hr
2. additionpoured onto ice water
3. extractionExtraction
4. customwith ethyl acetate and evaporation of the solvent in vacuo
5. customafforded a residue which
6. customwas triturated with diethyl ether