HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Chlorophenoxy)pyrrolidine → N-{2-[(3-[3-[(4-Chlorophenyl)oxy]-1-pyrrolidinyl}-2-hydroxy-1-methylpropyl)oxy]phenyl}acetamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Chlorophenoxy)pyrrolidine | HCID 12999570 | — |
| Reactant | N-[2-(1-oxiranylethoxy)phenyl]acetamide | HCID 22313695 | — |
| Product | N-{2-[(3-[3-[(4-Chlorophenyl)oxy]-1-pyrrolidinyl}-2-hydroxy-1-methylpropyl)oxy]phenyl}acetamide Hydrochloride | HCID 22313656 | 100% |
Reaction Steps
The title compound (230 mg, 100%) was prepared from N-[2-(1-oxiranylethoxy)phenyl]acetamide diasteromer 2 (123 mg, 0.557 mmol) and 3-(4-chlorophenoxy)pyrrolidine (100 mg, 0.506 mmol) analogously to that described in Example 1 (iii).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06927222B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-6a33480cbff64924bf4d899f4c97ab19 |
| Source note | uspto-grants-2005_08 |