Triethylamine → HCID 178509202, compound

Participants

Reaction Steps

To a solution of 2,6,7-trichloro-3-chloromethylquinoxaline (107 mg, 0.38 mmol) in DMF (5 ml) was added 3-amino-5-mercapto-1,2,4-triazole (44 mg, 0.38 mmol) followed by addition of triethylamine (0.05 ml, 0.38 mmol). After 5 hours, potassium fluoride 40% wt on alumina (143 mg, 1.1 mmol) was added, followed by 1,4 dioxa-8-aza-spiro[4,5]decane (0.05 ml, 0.42 mmol). The reaction was stirred overnight at room temperature. Purification by flash column chromatography using ethyl acetate afforded the title compound.

Provenance & Evidence