Phosphorus tribromide → HCID 20821149, compound

HRID 584680Notes

Reaction equation

HRID 584680 reaction equation
[C:1]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=O)[C:13]([C:20]([F:23])([F:22])[F:21])=[N:12]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:25]>>[Br:25][C:14]1[C:13]([C:20]([F:23])([F:22])[F:21])=[N:12][C:11]2[C:16](=[CH:17][CH:18]=[C:9]([C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:8])[CH:10]=2)[N:15]=1

Participants

3

Reactant 2

HCID 24614Phosphorus tribromideHCID 10245305HCID 10245305, compound

Product 1

HCID 20821149HCID 20821149, compound

Procedure

A mixture of 6-benzoyl-3-trifluoromethylquinoxalin-2(1H)-one (1.0 g, 3.13 mmol) [J. Org. Chem. 57(21). 5630,1992] and 10 ml of phosphorous tribromide was refluxed for 5 hours. The mixture was cooled and poured into ice water and the precipitate was isolated, washed with water and dried. Yield 0.87 g (73%) of the title compound as beige crystals.

Workup

  1. temperaturewas refluxed for 5 hours
  2. temperatureThe mixture was cooled
  3. customthe precipitate was isolated
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-f9068a07e6df4d288ed48d67dd618783
Source dataset
uspto-grants-2005_08
Patent number
US06927214B1

Reaction notes

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