反应详情

A mixture of 2-(4-methoxyphenyl)hydrazinecarbothioamide (0.5 g, 2.53 mmol), 4-methoxybenzoyl chloride (541 mg, 3.17 mmol), and pyridine (0.256 mL, 3.17 mmol) intoluene (10 mL) was refluxed for 1 hour. After cooling, the solvent was removed under reduced pressure. diisopropyl ether and small amount of methanol was added to the residue and a generated precipitate was isolated by filtration, washed with methanol-diisopropyl ether, and dried in vacuo to give 2-(4-methoxybenzoyl)-2-(4-methoxyphenyl)hydrazinecarbothioamide (277 mg, 33% yield).

1. temperaturewas refluxed for 1 hour
2. temperatureAfter cooling
3. customthe solvent was removed under reduced pressure
4. additiondiisopropyl ether and small amount of methanol was added to the residue
5. customa generated precipitate was isolated by filtration
6. washwashed with methanol-diisopropyl ether
7. customdried in vacuo