4-(Chloromethyl)-1,3-thiazole hydrochloride → 1,5-bis(4-methoxyphenyl)-3-(1,3-thiazol-4-ylmethoxy)-1H-1,2,4-triazole

HRID 584752Notes

Reaction equation

HRID 584752 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:12][C:11]([OH:22])=[N:10]2)=[CH:5][CH:4]=1.Cl.Cl[CH2:25][C:26]1[N:27]=[CH:28][S:29][CH:30]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:12][C:11]([O:22][CH2:25][C:26]3[N:27]=[CH:28][S:29][CH:30]=3)=[N:10]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 1784890151,5-bis(4-methoxyphenyl)-1H-1,2,4-triazol-3-ol

Product 1

HCID 101787491,5-bis(4-methoxyphenyl)-3-(1,3-thiazol-4-ylmethoxy)-1H-1,2,4-triazoleYield 49.7%

Procedure

1,5-bis(4-methoxyphenyl)-3-(1,3-thiazol-4-ylmethoxy)-1H-1,2,4-triazole (132 mg, 49.7% yield) was prepared from 1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazol-3-ol and 4-(chloromethyl)-1,3-thiazole hydrochloride by the similar manner described for Example 18.

Sources & evidence

ORD record
ord-e92a754fc571415793178f109a9c26ab
Source dataset
uspto-grants-2005_08
Patent number
US06927230B2

Reaction notes

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