1-Bromo-2-butyne → HCID 10291469, compound

HRID 584754Notes

Reaction equation

HRID 584754 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:12][C:11]([OH:22])=[N:10]2)=[CH:5][CH:4]=1.Br[CH2:24][C:25]#[C:26][CH3:27]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:12][C:11]([O:22][CH2:24][C:25]#[C:26][CH3:27])=[N:10]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 1784890151,5-bis(4-methoxyphenyl)-1H-1,2,4-triazol-3-ol

Product 1

HCID 10291469HCID 10291469, compoundYield 40.8%

Procedure

1,5-bis(4-methoxyphenyl)-3-(2-butynyloxy)-1H-1,2,4-triazole (96 mg, 40.8% yield) was prepared from 1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazol-3-ol and 1-bromo-2-butyne by the similar manner described for Example 18.

Sources & evidence

ORD record
ord-7926951e41e64d1d93eaa33c7a1c2bc2
Source dataset
uspto-grants-2005_08
Patent number
US06927230B2

Reaction notes

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