4-Fluorobenzaldehyde → HCID 22341802, compound

Participants

Reaction Steps

Prepared similarly to Example 3 with reductive amination using 4-fluorobenzaldehyde, and the use of 2-formylphenylboronic acid. Prepared in 34% overall yield without isolation of intermediates starting from the product of Example 1. 1H NMR (500 MHz, DMSO-d6) δ 10.37 (s, 1H), 7.83-7.79 (m, 1H), 7.64-7.60 (m, 1H), 7.40-7.34 (m, 2H), 7.29-7.19 (m, 3H), 7.70-6.95 (m, 5H), 6.32 (s, 1H), 5.09 (d, J=15.4 Hz, 1H), 5.01 (d, J=15.4 Hz, 1H), 4.56 (d, J=15.3 Hz, 1H), 4.47 (d, J=15.3 Hz, 1H).

Provenance & Evidence