N-(2-Acetyl-phenyl)-2,3-dihydroxy-3-methyl-butyramide → N-[2-(1-Allylamino-ethyl)-phenyl]-2,3-dihydroxy-3-methyl-butyramide

Participants

Reaction Steps

Prepared analogously to Example 11, starting with the product of Example 13 in 29% isolated yield (mixture of diastereomers), from flash column chromatography in ethyl acetate-hexane (3:2 to 4:1). 1H NMR (250 MHz, CDCl3) δ 8.35-8.18 (m, 1H), 7.30-7.19 (m, 1H), 7.15-6.98 (m, 2H), 5.99-5.77 (m, 1H), 5.23-5.03 (m, 2H), 4.06-3.91 (m, 2H), 3.13 (d, J=5.6 Hz, 2H), 1.42 (d, J=6.7 Hz, 3H), 1.31 (s, 3H), 1.29 (d, J=2.5 Hz, 3H).

Provenance & Evidence