Water → HCID 22249963, compound

HRID 584830Notes

Reaction equation

HRID 584830 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([CH3:20])[C:10]([C:11]3[C:16]([CH3:17])=[CH:15][C:14]([CH3:18])=[CH:13][C:12]=3[CH3:19])=[C:6]2[N:5]=[C:4]([CH3:21])[C:3]=1[CH2:22][CH2:23]Cl.NC(N)=[S:27].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[C:16]1([CH3:17])[CH:15]=[C:14]([CH3:18])[CH:13]=[C:12]([CH3:19])[C:11]=1[C:10]1[C:9]([CH3:20])=[N:8][N:7]2[C:2]3[S:27][CH2:23][CH2:22][C:3]=3[C:4]([CH3:21])=[N:5][C:6]=12

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 2723790ThioureaHCID 22249724HCID 22249724, compound

Product 1

HCID 22249963HCID 22249963, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7-chloro-6-(2-chloroethyl)-3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidine (500 mg, 1.38 mmol), thiourea (105 mg, 1.38 mmol) and sodium carbonate (180 mg, 1.73 mmol) in ethanol (10 mL) was heated under reflux for one hour. After overnight, water was added and the resulting crystals were collected by filtration. The crystals were washed with water, to give the title compound (436 mg) as white crystals.

Workup

  1. temperatureunder reflux for one hour
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were washed with water

Sources & evidence

ORD record
ord-4378ab4122e54455a31a87962a752d4c
Source dataset
uspto-grants-2005_08
Patent number
US06927221B2

Reaction notes

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