Hydrogen Peroxide → HCID 87887145, compound

Participants

Reaction Steps

0.64 g (2 mmol) of rac-10-acetyl-2,3-dimethyl-9-phenyl-9,10-dihydroimidazo[1,2-h][1,7]naphthyridine (racemic) are dissolved in 3 ml of acetonitrile and 1 ml of methanol and treated with 0.18 g (1.2 mmol) of potassium carbonate. 0.2 ml of hydrogen peroxide solution (30% in water) is then slowly added dropwise with ice cooling. The mixture is then allowed to warm to room temperature and is stirred for 16 h. After addition of saturated sodium hydrogencarbonate solution, it is extracted with dichloromethane. The organic phase is dried over magnesium sulfate and evaporated. The residue is purified by chromatography on silica gel (eluent diethyl ether/triethylamine 9:1). After crystallization from diethyl ether, 80 mg (12%) of the title compound are isolated as a colorless solid (m.p. 222° C.).

Provenance & Evidence