5-Amino-2-nitrobenzoic acid → 2-Nitro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid

HRID 584859노트

반응식

HRID 584859 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:14][C:15]1[C:22]([F:23])=[C:21]([C:24]([F:27])([F:26])[F:25])[C:20]([F:28])=[C:19]([F:29])[C:16]=1[CH2:17]Br>>[N+:11]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][CH2:17][C:16]2[C:19]([F:29])=[C:20]([F:28])[C:21]([C:24]([F:25])([F:27])[F:26])=[C:22]([F:23])[C:15]=2[F:14])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])([O-:13])=[O:12]

참가 물질

3

반응물 2

HCID 832985-Amino-2-nitrobenzoic acidHCID 1271374-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide

생성물 1

HCID 102510932-Nitro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid수율 76.3%

실험 절차

According to the similar procedure in Synthesis Example 1, by using 5-amino-2-nitrobenzoic acid (1.03 g, 5.65 mmole) and 2,3,5,6-tetrafluoro-4-trifloromethylbenzyl bromide (1.01 g, 6.04 mmole)(ACROS, 33074-0010), 1.50 g (76.3% yield) of 2-nitro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a pale yellow solid.

후처리

  1. customAccording to the similar procedure in Synthesis Example 1

출처 및 근거

ORD 기록
ord-3aedd456262b402790412b269e953c99
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927303B2

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