Thiazolidinedione → HCID 87953796, compound

HRID 584893Notes

Reaction equation

[CH3:1][N:2]([CH2:9][C:10]1[CH:11]=[C:12]([C:16]2[CH:21]=[CH:20][C:19]([CH:22]=O)=[CH:18][CH:17]=2)[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[S:24]1[CH2:28][C:27](=[O:29])[NH:26][C:25]1=[O:30]>>[CH3:1][N:2]([CH2:9][C:10]1[CH:11]=[C:12]([C:16]2[CH:17]=[CH:18][C:19]([CH:22]=[C:28]3[S:24][C:25](=[O:30])[NH:26][C:27]3=[O:29])=[CH:20][CH:21]=2)[CH:13]=[CH:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 86591248HCID 86591248, compound

Product 1

HCID 87953796HCID 87953796, compoundYield 86.2%

Procedure

In a manner similar to that of Example 1(f), by reacting 610 mg (1.85 mmol) of 3′-[(methylpyrid-2-ylamino)methyl]biphenyl-4-carbaldehyde with 216 mg (1.85 mmol) of 2,4-thiazolidine dione, 640 mg (81%) of expected product are obtained.

Sources & evidence

ORD record: ord-b18682f245c744a4832ad2fc3a0610cf
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06927228B2

Reaction notes

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