Ammonia → HCID 10110708, compound

Participants

Reaction Steps

By reacting a solution of 1.7 g (4.1 mmol) of 3-(3′-{[methyl-(1-phenylmethanoyl)amino]-methyl}biphenyl-4-yl)propionyl chloride in 5 ml of THF with 10 ml of aqueous ammonia, and after purification by chromatography on a column of silica, 200 mg (32%) of N-[4′-(2-carbamoylpropyl)biphenyl-3-ylmethyl]-N-methylbenzamide, with a melting point of 47-48° C., are obtained.

Provenance & Evidence