Benzylamine → HCID 10226630, compound

Participants

Reaction Steps

By reacting a solution of 637 mg (1.6 mmol) of 3-(3′-{[methyl-(1-phenylmethanoyl)amino]-methyl}biphenyl-4-yl)propionyl chloride in 5 ml of THF with 146 μl (1.6 mmol) of benzylamine in the presence of 250 μl (1.8 mmol) of triethylamine (1.6 mmol), and after purification by chromatography on a column of silica, 370 mg (50%) of N-methyl-N-[4′-(2-phenyl-carbamoylpropyl)biphenyl-3-ylmethyl]benzamide, with a melting point of 68-69° C., are obtained.

Provenance & Evidence