Triethylamine → HCID 10157949, compound

Participants

Reaction Steps

By reacting a solution of 669 mg (1.65 mmol) of 3-(3′-{[methyl-(1-phenylmethanoyl)amino]-methyl}biphenyl-4-yl)propionyl chloride in 6 ml of THF with 243 mg (1.65 mmol) of O-(tert-butyldimethyl-silyl) hydroxylamine in the presence of 250 μl (1.8 mmol) of triethylamine, followed by deprotection with 530 μl of tetrabutylammonium fluoride solution (1N in THF), and after purification by chromatography on a column of silica, 350 mg (42%) of N-[4′-(2-hydroxy-carbamoylpropyl)biphenyl-3-ylmethyl]-N-methylbenzamide, with a melting point of 65-66° C., are obtained.

Provenance & Evidence