Thiazolidinedione → HCID 90839152, compound

HRID 584904Notes

Reaction equation

[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][C:17]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[CH:10]=2)=[CH:5][CH:4]=1)=O.[S:26]1[CH2:30][C:29](=[O:31])[NH:28][C:27]1=[O:32]>>[O:32]=[C:27]1[NH:28][C:29](=[O:31])[C:30](=[CH:1][C:3]2[CH:4]=[CH:5][C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][C:17]([NH:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[O:18])[CH:10]=3)=[CH:7][CH:8]=2)[S:26]1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 22341490HCID 22341490, compound

Product 1

HCID 90839152HCID 90839152, compoundYield 53%

Procedure

In a manner similar to that of Example 1(f), by reacting 2.1 g (6.4 mmol) of 1-(4′-formylbiphenyl-3-ylmethyl)-3-phenylurea with 750 mg (6.4 mmol) of 2,4-thiazolidine dione, 1.4 g (53%) of the expected product are obtained.

Sources & evidence

ORD record: ord-0620150b7e4b40f4b7c03187d0b11f0c
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06927228B2

Reaction notes

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