Bicarbonate Ion → 5-(3'-Methylaminomethylbiphenyl-4-ylidene-methyl) thiazolidine-2,4-dione

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Reaction Steps

2 g (4.7 mmol) of tert-butyl [4′-(2,4-dioxo-thiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]methyl-carbamate and 20 ml of dichloromethane are introduced into a round-bottomed flask. 2.2 ml (28.2 mmol) of trifluoroacetic acid are added and the mixture is stirred at room temperature for four hours. The reaction medium is poured into aqueous bicarbonate solution and extracted with dichloromethane, and the organic phase is separated out after settling of the phases has taken place, dried over magnesium sulfate and evaporated. 1.3 g (85%) of the expected product are obtained.

Provenance & Evidence