Ethylene Glycol → HCID 22341453, compound

Participants

Reaction Steps

3.2 g (10 mmol) of N-(4-formylbiphenyl-3-yl-methyl)benzamide, 50 ml of toluene, 2.8 ml (50 mmol) of ethylene glycol and 38 mg (0.2 mmol) of para-toluenesulfonic acid are introduced into a three-necked flask under a stream of nitrogen. The reaction medium is refluxed for 3 hours and the water formed is separated off using Dean-stark apparatus. The reaction medium is extracted with dichloromethane and washed with water, and the organic phase is separated out after settling of the phases has taken place. The organic phase is dried over magnesium sulfate and filtered. 3.7 g (100%) of the desired product are obtained.

Provenance & Evidence