Thiazolidinedione → HCID 86591250, compound

HRID 584921Notes

Reaction equation

HRID 584921 reaction equation
[CH2:1]([N:3]([CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[CH:24]=[CH:23][C:22]([CH:25]=O)=[CH:21][CH:20]=2)[CH:16]=[CH:17][CH:18]=1)[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[S:27]1[CH2:31][C:30](=[O:32])[NH:29][C:28]1=[O:33]>>[O:33]=[C:28]1[NH:29][C:30](=[O:32])[C:31](=[CH:25][C:22]2[CH:21]=[CH:20][C:19]([C:15]3[CH:16]=[CH:17][CH:18]=[C:13]([CH2:12][N:3]([CH2:1][CH3:2])[C:4](=[O:11])[C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=4)[CH:14]=3)=[CH:24][CH:23]=2)[S:27]1

Participants

3

Reactant 2

HCID 5437ThiazolidinedioneHCID 22341416HCID 22341416, compound

Product 1

HCID 86591250HCID 86591250, compoundYield 88%

Procedure

In a manner similar to that of Example 1(f), by reacting 300 mg (0.9 mmol) of N-ethyl-N-(4′-formyl-biphenyl-3-ylmethyl)benzamide with 100 mg (0.9 mmol) of 2,4-thiazolidine dione, 340 mg (88%) of the expected product are obtained.

Sources & evidence

ORD record
ord-090cdd1a8144419b9d9084c69c50c07c
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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