Thiazolidinedione → HCID 86588730, compound

HRID 584926Notes

Reaction equation

[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:10]=2)=[CH:5][CH:4]=1)=O.[S:24]1[CH2:28][C:27](=[O:29])[NH:26][C:25]1=[O:30]>>[O:30]=[C:25]1[NH:26][C:27](=[O:29])[C:28](=[CH:1][C:3]2[CH:4]=[CH:5][C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH:10]=3)=[CH:7][CH:8]=2)[S:24]1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 86761347HCID 86761347, compound

Product 1

HCID 86588730HCID 86588730, compoundYield 95%

Procedure

In a manner similar to that of Example 1(f) by reacting 7.4 g (24 mmol) of tert-butyl (4′-formyl-biphenyl-3-ylmethyl)carbamate (prepared as in Example 1(e) from tert-butyl (3-bromo benzyl)carbamate)with 2.8 g (24 mmol) of 2,4-thiazolidine dione, 9 g (95%) of the expected product are obtained.

Sources & evidence

ORD record: ord-6c2439fb16d346558f72dad9271b3f4f
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06927228B2

Reaction notes

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