1-Bromopropane → HCID 90914186, compound

HRID 584927Notes

Reaction equation

[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1.Br[CH2:31][CH2:32][CH3:33]>>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH2:31][CH2:32][CH3:33])[C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:28])[CH3:27])[CH:16]=3)=[CH:13][CH:14]=2)[S:3]1

Participants

Reactant 2

HCID 78401-Bromopropane

HCID 86588730HCID 86588730, compound

Product 1

HCID 90914186HCID 90914186, compoundYield 78%

Procedure

In a manner similar to that of Example 17(d), starting with 700 mg (1.7 mmol) of tert-butyl [4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]carbamate and 350 μl (3.8 mmol) of 1-bromopropane, 600 mg (78%) of the desired product are obtained.

Sources & evidence

ORD record: ord-a58f1cb5e74a44db87cdb343e0da0efe
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06927228B2

Reaction notes

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