HCID 86591253, compound → HCID 10166066, compound

HRID 584930Notes

Reaction equation

HRID 584930 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH3:40])[C:23](=[O:39])[O:24][CH2:25][CH:26]4[C:38]5[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=5[C:32]5[C:27]4=[CH:28][CH:29]=[CH:30][CH:31]=5)[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1>O1CCOCC1>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH3:40])[C:23](=[O:39])[O:24][CH2:25][CH:26]4[C:38]5[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=5[C:32]5[C:27]4=[CH:28][CH:29]=[CH:30][CH:31]=5)[CH:16]=3)=[CH:13][CH:14]=2)[S:3]1

Participants

3

Reactant 1

HCID 86591253HCID 86591253, compound

Product 1

HCID 10166066HCID 10166066, compoundYield 40.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 500 mg (0.9 mmol) of 9H-fluoren-9-ylmethyl [4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]methylcarbamate in 10 ml of dioxane, 200 mg (40%) of the desired product, with a melting point of 94° C., are obtained.

Sources & evidence

ORD record
ord-2161c94f6dee438f9ee08b38423b8311
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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