Methanol → HCID 86591254, compound

Participants

Reaction Steps

12.6 g (37 mmol) of ethyl 4′-(2,4-dioxo-thiazolidin-5-ylidenemethyl)biphenyl-3-carboxylate, 150 ml of tetrahydrofuran, 15 ml of methanol, a few drops of water and 7.4 g (186 mmol) of sodium hydroxide pellets are introduced into a round-bottomed flask. The mixed is refluxed for 18 hours. The reaction medium is placed in water, acidified to pH 2 and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and evaporated. 11.4 g (94%) of the desired product are obtained.

Provenance & Evidence