HCID 86591255, compound → HCID 10225156, compound

Participants

Reaction Conditions

Reaction Steps

150 mg (0.35 mmol) of N-octyl-4′-(2,4-dioxo-thiazolidin-5-ylidenemethyl)biphenyl-3-carboxamide, 20 ml of dimethylformamide and 150 mg of palladium-on-charcoal (10%) are introduced into a reactor under a stream of nitrogen. The medium is heated at 80° C. and hydrogenated under a pressure of 3 atm for 5 hours. The reaction medium is filtered through Celite. The filtrate is placed in water, extracted with ethyl acetate and washed thoroughly with water. The organic phase is dried over magnesium sulfate, filtered and evaporated. The residue is chromatographed on a column of silica, eluted with a mixture of heptane and ethyl acetate (30/70). 100 mg (65%) of the expected product, with a melting point of 137-138° C., are obtained.

Provenance & Evidence