Thiazolidinedione → HCID 131725063, compound

HRID 584939Notes

Reaction equation

HRID 584939 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][C:17]([N:19]([CH3:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[CH:11]=2)=[CH:6][CH:5]=1)(=O)C.[S:27]1[CH2:31][C:30](=[O:32])[NH:29][C:28]1=[O:33]>>[O:33]=[C:28]1[NH:29][C:30](=[O:32])[C:31](=[CH:1][C:4]2[CH:5]=[CH:6][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][C:17]([N:19]([CH3:26])[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[O:18])[CH:11]=3)=[CH:8][CH:9]=2)[S:27]1

Participants

3

Reactant 2

HCID 5437ThiazolidinedioneHCID 22341497HCID 22341497, compound

Product 1

HCID 131725063HCID 131725063, compoundYield 71%

Procedure

In a manner similar to that of Example 1(f), by reacting 1 g (4 mmol) of 2-(4′-acetylbiphenyl-3-yl)-N-methyl-N-phenylacetamide with 460 mg (4 mmol) of 2,4-thiazolidine dione, 1.2 g (71%) of the expected product are obtained.

Sources & evidence

ORD record
ord-596b34cf9da845b1a30762ac6a57d726
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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