Thiazolidinedione → HCID 86591257, compound

HRID 584942Notes

Reaction equation

HRID 584942 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]([CH2:25][CH2:26][CH3:27])[C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:10]=2)=[CH:5][CH:4]=1)=O.[S:28]1[CH2:32][C:31](=[O:33])[NH:30][C:29]1=[O:34]>>[O:34]=[C:29]1[NH:30][C:31](=[O:33])[C:32](=[CH:1][C:3]2[CH:4]=[CH:5][C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]([CH2:25][CH2:26][CH3:27])[C:17](=[O:24])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:10]=3)=[CH:7][CH:8]=2)[S:28]1

Participants

3

Reactant 2

HCID 5437ThiazolidinedioneHCID 22341535HCID 22341535, compound

Product 1

HCID 86591257HCID 86591257, compoundYield 72.6%

Procedure

In a manner similar to that of Example 1(f), by reacting 580 mg (1.6 mmol) of N-(4′-formylbiphenyl-3-ylmethyl)-N-propylbenzamide with 190 mg (1.6 mmol) of 2,4-thiazolidine dione, 530 mg (72%) of the expected product, with a melting point of 250-251° C., are obtained.

Sources & evidence

ORD record
ord-429458fd3656430eb50b99d38fee2891
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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