HCID 86591259, compound → HCID 10272188, compound

HRID 584944Notes

Reaction equation

HRID 584944 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1>O1CCOCC1>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:26])([CH3:25])[CH3:27])[CH:16]=3)=[CH:13][CH:14]=2)[S:3]1

Participants

3

Reactant 1

HCID 86591259HCID 86591259, compound

Product 1

HCID 10272188HCID 10272188, compoundYield 97.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 700 mg (1.8 mmol) of tert-butyl [4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-yl]carbamate in 10 ml of dioxane, 700 mg (60%) of the desired product, with a melting point of 158° C., are obtained.

Sources & evidence

ORD record
ord-cdd3a34c89ab49148c6cb4a54b2c1eb3
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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