Phenethylamine → HCID 86591261, compound

Participants

Reaction Steps

500 mg (1.54 mmol) of 4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-carboxylic acid (prepared in Example 23(c)), 5 ml of dimethylformamide, 230 mg (1.7 mmol) of 1-hydroxybenzotriazole and 200 μl (1.5 mmol) of benzylmethylamine are introduced into at three-necked flask under a stream of nitrogen. At 0° C., 350 mg (1.7 mmol) of dicyclohexylcarbodiimide are added portionwise. The mixture is stirred for 18 hours while allowing the temperature to rise. The reaction medium is immersed in water, extracted with ethyl acetate, dried over magnesium sulfate, filtered and evaporated. The residue obtained is washed with dichloromethane and filtered. 400 mg (61%) of the desired product are obtained.

Provenance & Evidence