Phenylacetyl chloride → HCID 86591265, compound

HRID 584952Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]=[C:15]3[S:19][C:18](=[O:20])[NH:17][C:16]3=[O:21])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:22]1([CH2:28][C:29](Cl)=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[O:20]=[C:18]1[NH:17][C:16](=[O:21])[C:15](=[CH:14][C:11]2[CH:10]=[CH:9][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:29](=[O:30])[CH2:28][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:3]=3)=[CH:13][CH:12]=2)[S:19]1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 86591264HCID 86591264, compound

Product 1

HCID 86591265HCID 86591265, compoundYield 97%

Procedure

In a manner similar to that of Example 1(d), by reacting 1.2 g (2.3 mmol) of 5-(3′-aminobiphenyl-4-ylmethylene)thiazolidine-2,4-dione with 430 μl (3 mmol) of phenylacetyl chloride, 920 mg (97%) of the expected product are obtained.

Sources & evidence

ORD record: ord-e3cdb00d9e964d23bf2a55798b175b88
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06927228B2

Reaction notes

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