HCID 86591267, compound → HCID 10203529, compound

HRID 584954Notes

Reaction equation

HRID 584954 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH3:31])[C:23](=[O:30])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1>O1CCOCC1>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH3:31])[C:23](=[O:30])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1

Participants

3

Reactant 1

HCID 86591267HCID 86591267, compound

Product 1

HCID 10203529HCID 10203529, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 360 mg (0.8 mmol) of N-[4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]-N-methylheptanamide in 15 ml of dioxane, under 3 atm, 230 mg (66%) of the desired product are obtained in the form of a colorless film.

Sources & evidence

ORD record
ord-ed76c521344342108a0fa42f46e124b7
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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