m-Anisoyl chloride → N-[4'-(2,4-Dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-3-methoxy-N-methylbenzamide

Participants

Reaction Steps

In a manner similar to that of Example 37(e), by reacting 540 mg (1.2 mmol) of 5-(3′-methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoroacetate with 300 μl (2 mmol) of 3-methoxybenzoyl chloride, and after purification, 400 mg (70%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)-biphenyl-3-ylmethyl]-3-methoxy-N-methylbenzamide are obtained in the form of a white solid with a melting point of 173° C.

Provenance & Evidence