4-Propylbenzoyl chloride → N-[4'-(2,4-Dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methyl-4-propylbenzamide

Participants

Reaction Steps

In a manner similar to that of Example 37(e), by reacting 500 mg (1.1 mmol) of 5-(3′-methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoroacetate with 210 μl (1.2 mmol) of 4-propylbenzoyl chloride and after purification, 300 mg (55%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)-biphenyl-3-ylmethyl]-N-methyl-4-propylbenzamide, with a melting point of 280° C., are obtained.

Provenance & Evidence